A new flavonoid compound is being used by a faculty member in the College of Pharmacy during advanced scientific research.
In an academic achievement added to the record of the College of Pharmacy at Al-Zahraa University for Girls, Lecturer M.M. Safaa Redha Mahdi published a scientific paper in the International Journal of Ecosystems and Ecology Science, which is classified within Scopus Q4.
The study dealt with the manufacture of a new (flavonoid) derivative (C1) and studying its effect in reducing the toxicity of (chlorpyrifos): a commonly used insecticide, by reducing oxidative stress in male rats.
The laboratory animals were divided into four groups. The first group was given corn oil, the second group consumed only the new compound, the third group was exposed to chlorpyrifos alone, and the last group received both the compound and chlorpyrifos for two weeks.
The results demonstrated a significant increase in oxidative stress markers upon exposure to chlorpyrifos, while the new compound (C1) showed a high capacity to improve biochemical parameters and reduce lipid peroxidation. Furthermore, prophylactic doses of the compound prior to chlorpyrifos exposure significantly reduced markers of metabolic damage.
Computer analysis (ADME) predicted that the compound would have low toxicity, high bioavailability and good pharmacodynamic stability, making it a promising candidate as a protective antioxidant compound, capable of neutralizing free radicals and protecting the kidneys and liver from damage.
This scientific achievement reflects the keenness of the staff of the College of Pharmacy at Al-Zahraa University for Girls to contribute effectively to sound scientific research that meets global trends towards finding safer and more effective drug alternatives.