Dr. Diaa Rahim Al-Tamimi, a faculty member at the College of Pharmacy at Al-Zahraa University for Girls, achieved a scientific accomplishment by publishing his research entitled بعنوان:
“SILK FIBROIN-COATED MESOPOROUS SILICA NANOPARTICLES ENHANCE 6-THIOGUANINE DELIVERY AND CYTOTOXICITY IN BREAST CANCER CELLS”
In a magazine:
International Journal of Applied Pharmaceutics
Global, indexed in Scopus, and located in the second quarter (Q2) journals.
This study aims to develop an advanced nanosystem to improve the delivery efficiency of 6-thioguanine, a drug used in breast cancer chemotherapy. Breast cancer is one of the most common cancers among women worldwide, and traditional treatments often face challenges such as poor drug solubility and low drug delivery efficiency to cancer cells. Therefore, the researcher designed a nanosystem based on porous silica nanoparticles (MSNs) loaded with the drug and coated with Silk Fibroin protein to enhance pharmacokinetic properties and increase targeting efficiency to breast cancer cells.
The study included assessing the cytotoxicity of the different constructs using the MTT assay, as well as analyzing cell death.