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Co-crystallisation as a powerful solubilization approach for Biopharmaceutical ( Classification System Class II drugs)
The research titled "Co-crystallisation as a Powerful Solubilization Approach for Biopharmaceutical
(Classification System Class II Drugs)
was published by tutors Lect. Dr. Asma' Abd Al-Aziz Mohammed along with Dr. Noor Zuhair Abd Al-Ghani in "Al-Zahraa Journal for Health and Medical Sciences". The study explores co-crystallization as an effective strategy to enhance the solubility of Class II drugs under the Biopharmaceutical Classification System (BCS). In addition, these drugs are characterized by low solubility and high permeability, which presents challenges in drug formulation. Co-crystallization has been developed as a technique to improve the solubility of poorly soluble drugs. Additionally, this approach is often considered one of the most efficient methods to enhance the quality of pharmaceuticals, as it can modify the molecular interactions and chemical structures of medicinal substances. Co-crystals provide an alternative strategy for active pharmaceutical ingredients (APIs), regardless of whether they contain acidic, basic, or ionizable groups. Furthermore, the review addresses such aspects of co-crystallization as its design, preparation, and characterization, along with numerous applied research studies. Furthermore, the article highlights the significance of co-crystallization in the amelioration of several physical and chemical properties of BCS Class II drugs, such as solubility, stability, as well as bioavailability.
