Lect. Dr. Asma' Abd Al-Aziz Mohammed, a faculty member at Pharmacy faculty, Al-Zahraa University for Women, has published her research titled “Orally Disintegrating Tablets: Formulation, Preparation, and Quality Control Assessment” in the international journal European Journal of Scientific Research and Reviews.
The study focused on the technologies used in the development of orally disintegrating tablets (ODTs),
a new dosage form that dissolves in saliva within seconds without the need for water. Due to their numerous advantages, ODTs are an effective drug delivery method, particularly for pediatric and elderly patients.
The research discussed the use of specific materials to enhance the properties of ODTs, including super disintegrants like croscarmellose sodium and crospovidone to achieve rapid disintegration and dissolution. It also explored the use of sweeteners, flavoring agents, as well as solubility enhancers to optimize the tablets’ performance.
It bears noting that various preparation techniques for ODTs were reviewed, such as direct compression, sublimation, freeze-drying, along with spray drying. The study also examined the formulation process, selection of appropriate excipients, and pre-compression powder flow properties. Furthermore, the quality control assessment of the ODTs was comprehensively evaluated to ensure their effectiveness and reliability.
