A new research achievement by a faculty member in the College of Pharmacy
Lecturer Dr. Nafisa Qurban Ali from the College of Pharmacy published a scientific paper entitled:
“Novel diazen-bis(phenoxy-1,2,3-triazole-N-phenylacetamide) derivatives as potent anti-cholinesterase, anti-α-glycosidase and anti-α-amylase agents: In vitro and in silico evaluations”
The research, which was published in the Journal of Molecular Structure, indexed in Scopus and Clarivate and in the second quartile (Q2), is a research achievement that reflects the advanced scientific level of the faculty members at the college.
The research addressed the design and manufacture of new derivatives of diazene-base compounds (phenoxy-1,2,3-triazol-N-phenylacetamide) (9a-n) and studied their effectiveness as inhibitors of biosynthetic enzymes associated with common diseases such as Alzheimer's and diabetes.
Laboratory results showed that some of the manufactured compounds provided a strong and promising inhibitory effect, as compound (9h) was superior in inhibiting the enzymes (acetylcholinesterase, butyrylcholinesterase) and was nearly twice as effective as the standard inhibitor (tacrine), while compound (9i) showed effectiveness against the enzyme (alpha-amylase) and was about 3.8 times more effective than the standard drug (acarbose).
Molecular modeling studies have also demonstrated that these compounds have a high binding capacity to the active sites of the targeted enzymes, which enhances the possibility of adopting them as prototypes for the development of (new drugs for the treatment of Alzheimer’s and diabetes).
Publishing this research in a reputable international journal enhances the college’s academic and research standing, and opens new horizons for applied research in the field of drug and treatment design, which is of great importance at the present time.